The series is set in the late 21st or early 22nd century. There are many "outpost"/settlement worlds in the galaxy, with heavy western influenced names, such as "Planet Uma" and "Planet Durango". Oddly enough, most of these worlds have only humanoid lifeforms on them. Not many aliens encountered.

It's not often that two themes are melded together so perfectly. In "Saber Rider and the Star Sheriffs", the themes of the Old West, and the new themes of Science Fiction and Space Travel are combined together so smoothly, so consistently, so special, that you wonder why can't all the newer animated TV series today be this good? The music even fits the western overtone theme and the mood of the stories, so there is the real feeling of the Old Frontier West (think Clint Eastwood), even though the series is set in the future, but not-that-distant end of the 21st century.

Ramrod was constructed by the Earth's Cavalry Command to battle the Outrider Renegade Units and defend the inhabitants of the New Frontier, and is doing a good job at both of the tasks. It's official name is "Ramrod Equalizer Unit", but everyone calls it "Ramrod" for short.